Kruger National Park is one of the largest game reserves in Africa. It covers 18,989 square kilometres (7,332 sq mi) and extends 350 kilometres (220 mi) from north to south and 60 kilometres (37 mi) from east to west.

To the west and south of the Kruger National Park are the two South African provinces of Limpopo and Mpumalanga. In the north is Zimbabwe, and to the east is Mozambique. It is now part of the Great Limpopo Transfrontier Park, a peace park that links Kruger National Park with the Gonarezhou National Park in Zimbabwe, and with the Limpopo National Park in Mozambique.

The park is part of the Kruger to Canyons Biosphere, an area designated by the United Nations Education and Scientific Organisation (UNESCO) as an International Man and Biosphere Reserve (the "Biosphere").

The park has 9 main gates that allow entrance to the different camps. The names of these gates are Paul Kruger Gate, Numbi Gate, Malelane Gate, Crocodile Bridge Gate, Punda Maria Gate, Orpen Gate, Phalaborwa Gate, Phabeni Gate and Pafuri Gate.

The park is the site of the popular eyewitness viral video Battle at Kruger.